What is COVID-19 “rebound” after treatment with Paxlovid?

It is possible for patients to have a brief return of COVID-19 symptoms between 2 and 8 days after initial recovery or a new positive test after COVID-19 treatment with Paxlovid, also known as a COVID-19 “rebound” period. 

If symptoms appear, or you receive a new positive test after previously testing negative, patients should restart the CDC-recommended isolation period. Continue to stay at home, rest, and take over-the-counter fever-reducing medications if needed. 

There is currently no evidence that additional treatment is needed with Paxlovid or other anti-SARS-CoV-2 therapies when COVID-19 rebound is suspected. You should contact their healthcare provider if you have any questions about medications or rebound symptoms.

Seek immediate in-person care if you experience any of the following:

• severe trouble breathing
• continuous pain or pressure in the chest 
• feeling confused 
• having difficulty waking up or staying awake
• pale, gray, or blue-colored skin, lips, or nail beds
• any other emergency signs or symptoms