What is COVID-19 “rebound” after treatment with Paxlovid?
It is possible for patients to have a brief return of COVID-19 symptoms between 2 and 8 days after initial recovery or a new positive test after COVID-19 treatment with Paxlovid, also known as a COVID-19 “rebound” period.
If symptoms appear, or you receive a new positive test after previously testing negative, patients should restart the CDC-recommended isolation period. Continue to stay at home, rest, and take over-the-counter fever-reducing medications if needed.
There is currently no evidence that additional treatment is needed with Paxlovid or other anti-SARS-CoV-2 therapies when COVID-19 rebound is suspected. You should contact their healthcare provider if you have any questions about medications or rebound symptoms.
Seek immediate in-person care if you experience any of the following:
- severe trouble breathing
- continuous pain or pressure in the chest
- feeling confused
- having difficulty waking up or staying awake
- pale, gray, or blue-colored skin, lips, or nail beds
- any other emergency signs or symptoms